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Metallic nanostructures based on blu-ray discs for multiplexed plasmonic biodetection

AutorLópez-Muñoz, Gerardo A.; Estévez, M. Carmen ; Homs-Corbera, A.; Berenguel-Alonso, M.; Alonso-Chamarro, J.; Lechuga, Laura M.
Fecha de publicación2017
CitaciónNyNA 2017
ResumenNanostructure-based plasmonic biosensors have quickly positioned themselves as interesting candidates for the design of portable optical biosensor platforms considering the potential benefits they can offer in miniaturization, multiplexing, real-time and label-free detection. We have developed a simple integrated nanoplasmonic sensor taking advantage of the periodic nanostructured array of commercial Blu-ray discs. Sensors with different metallic film layers (50 and 100 nm) were fabricated and optically characterized by varying the oblique-angle of the incident light in optical reflectance measurements. We observed an enhancement in sensitivity and a narrowing of the resonant linewidths as the light incidence angle was increased, which could be related to the generation of Fano resonant modes. The new sensors achieve a figure of merit (FOM) up to 35 RIU-1 and a competitive bulk limit of detection (LOD) of 6.34×10-6 RIU. Based on these structures, a single-channel sensor in a 1cm2 integrated chip has been designed an incorporated in a compact biosensor prototype. The label-free biosensing capability of the new sensor has been assessed by evaluating the presence of specific antibodies against the GTF2b protein, a tumor-associate antigen (TAA) related to colorectal cancer. We have achieved a LOD in the pM order and have evaluated the feasibility of directly measuring biological samples such as human serum. The design has been transferred and adapted to a multiplexed prototype incorporating a sensor chip with four integrated channels. The optical and the sensing performance have been evaluated. We have assessed bulk sensitivity and attempted real-time biosensing measurements, obtaining good reproducibility between the channels.
DescripciónResumen del trabajo presentado al VIII International Congress on Analytical Nanoscience and Nanotechnology, celebrado en Barcelona (España) del 3 al 5 de julio de 2017.
URIhttp://hdl.handle.net/10261/161293
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