English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/161243
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Gut microbiota trajectory in early life may predict development of celiac disease

AutorOlivares, Marta ; Walker, Alan W; Capilla, Amalia ; Benítez-Páez, Alfonso ; Palau Martínez, Francesc ; Parkhill, Julian; Castillejo, Gemma; Sanz Herranz, Yolanda
Fecha de publicación20-feb-2018
EditorBioMed Central
CitaciónMicrobiome 6(1): 36 (2018)
ResumenAbstract Background To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. Methods A nested case-control study was carried out as part of a larger prospective cohort study, which included healthy full-term newborns (> 200) with at least one first relative with biopsy-verified CD. The present study includes cases of CD (n = 10) and the best-matched controls (n = 10) who did not develop the disease after 5-year follow-up. Fecal microbiota, assessed by high-throughput 16S rRNA gene amplicon sequencing, and immune parameters were profiled at 4 and 6 months of age and related to CD onset. Results The microbiota of infants who remained healthy showed an increase in bacterial diversity over time, characterized by increases in Firmicutes families, but not those who developed CD. Infants who subsequently developed CD showed a significant reduction in sIgA levels over time, while those who remained healthy showed increases in TNF-α correlated to Bifidobacterium spp. An increased relative abundance of Bifidobacterium longum was associated with control children while increased proportions of Bifidobacterium breve and Enterococcus spp. were associated with CD development. Conclusion The findings suggest that alterations in the early trajectory of gut microbiota in infants at CD risk could influence the immune maturation process and predispose to CD, although larger population studies are warranted to confirm this hypothesis.
Versión del editorhttp://dx.doi.org/10.1186/s40168-018-0415-6
URIhttp://hdl.handle.net/10261/161243
DOI10.1186/s40168-018-0415-6
ISSN2049-2618
Aparece en las colecciones: (IBV) Artículos
(IATA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
40168_2018_Article_415.pdf1,17 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.