English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/161028
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Nanocomposite chitosan hydrogels based on PLGA nanoparticles as potential biomedical materials

AuthorsCaldas dos Santos, T.; Hernández, Rebeca ; Rescignano, Nicoletta ; Boff, L.; Reginatto, F. H.; Simões, C. M. O; Campos, A. M. de; Mijangos, Carmen
KeywordsCecropia glaziovii Snethl
PLGA nanoparticles
Thermosensitive hydrogel
Issue Date2018
CitationEuropean Polymer Journal 99: 456-463 (2018)
AbstractWe report on the preparation and characterization of nanocomposite chitosan hydrogels with embedded poly (lactic-co-glycolic acid) (PLGA) nanoparticles employed for encapsulation of an enriched flavonoid fraction of Cecropia glaziovii Snethl. As a first step, the experimental conditions to obtain homogeneous chitosan hydrogels at 37 °C through gelation with NaHCO were optimized. Then, nanocomposite chitosan hydrogels were prepared through direct incorporation of nanoparticlesat different concentrations ranging from 1 to 10% w/w to gelling aqueous chitosan solutions. The resulting hydrogels were characterized through Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), oscillatory rheological experiments and cytotoxicity tests. FT-IR spectra confirmed the PLGA nanoparticles presence within the chitosan matrix through the absorption peak located at 1750 cm. The presence of the PLGA nanoparticles decreased the thermal stability of the nanocomposite chitosan hydrogels compared to the pure chitosan hydrogel. SEM images allowed observing porous matrixes where nanoparticles appeared to be homogeneously dispersed. The elastic moduli found for nanocomposite chitosan hydrogels varied with the PLGA nanoparticles concentration with a maximum at 3% nanoparticles concentration. Cytotoxicity tests revealed that after 48 h, neither thepure hydrogel nor the nanocomposite chitosan hydrogels with 10% nanoparticles concentration showed toxicity on VERO cells.
Identifiersdoi: 10.1016/j.eurpolymj.2017.12.039
issn: 0014-3057
e-issn: 1873-1945
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.