English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/160844
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Influence of cerebral blood vessel movements on the position of perivascular synapses

AuthorsUrrecha, M.; Romero, I.; DeFelipe, Javier ; Merchán-Pérez, Ángel
Issue Date2017
PublisherPublic Library of Science
CitationPLoS ONE 12 (2017)
AbstractSynaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mechanical changes that blood vessel movements induce in the surrounding tissue have not been considered. We have modeled the mechanical changes that movements of blood vessels cause in neighboring synapses. Our simulations indicate that synaptic densities increase or decrease during vascular dilation and contraction, respectively, near the blood vessel walls. This phenomenon may alter the concentration of neurotransmitters and vasoactive substances in the immediate vicinity of the vessel wall and thus may have an influence on local blood flow.
URIhttp://hdl.handle.net/10261/160844
DOIhttp://dx.doi.org/10.1371/journal.pone.0172368
Identifiersdoi: 10.1371/journal.pone.0172368
issn: 1932-6203
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
Plos One 2017.htm823,39 kBHTMLView/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.