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Multilayered control of peroxisomal activity upon salt stress in Saccharomyces cerevisiae

AutorManzanares-Estreder, Sara ; Espí-Bardisa, Joan; Alarcón, Benito; Pascual-Ahuir, Amparo ; Proft, Markus
Palabras clavePeroxisome
Hog1
Adr1
Retrograde pathway
Stress adaptation
Yeast
Fecha de publicación10-abr-2017
EditorWiley-Blackwell
CitaciónMolecular Microbiology 104(5):851-868 (2017)
ResumenPeroxisomes are dynamic organelles and the sole location for fatty acid β-oxidation in yeast cells. Here, we report that peroxisomal function is crucial for the adaptation to salt stress, especially upon sugar limitation. Upon stress, multiple layers of control regulate the activity and the number of peroxisomes. Activated Hog1 MAP kinase triggers the induction of genes encoding enzymes for fatty acid activation, peroxisomal import and β-oxidation through the Adr1 transcriptional activator, which transiently associates with genes encoding fatty acid metabolic enzymes in a stress- and Hog1-dependent manner. Moreover, Na+ and Li+ stress increases the number of peroxisomes per cell in a Hog1-independent manner, which depends instead of the retrograde pathway and the dynamin related GTPases Dnm1 and Vps1. The strong activation of the Faa1 fatty acyl-CoA synthetase, which specifically localizes to lipid particles and peroxisomes, indicates that adaptation to salt stress requires the enhanced mobilization of fatty acids from internal lipid stores. Furthermore, the activation of mitochondrial respiration during stress depends on peroxisomes, mitochondrial acetyl-carnitine uptake is essential for salt resistance and the number of peroxisomes attached to the mitochondrial network increases during salt adaptation, which altogether indicates that stress-induced peroxisomal β-oxidation triggers enhanced respiration upon salt shock.
DescripciónVersión de autor: 40 páginas, 7 figuras, 2 tablas.
Versión del editorhttp://dx.doi.org/10.1111/mmi.13669
URIhttp://hdl.handle.net/10261/160808
DOI10.1111/mmi.13669
ISSN0950-382X
E-ISSN1365-2958
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