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Stimulated occurrence and biological activity of palmitoleic acid and its isomers in metabolic diseases

AutorMeana, Clara ; Guijas, Carlos ; Balboa, María A. ; Balsinde, Jesús
Fecha de publicación2016
CitaciónCIBERDEM Annual Meeting (2016)
ResumenAtherosclerosis, a major cause for cardiovascular disease, can be initiated by the increased activation of endothelial cells lining the inside of the blood vessels. This activation may obey to multiple causes, such as diabetes or hyperlipidemia, and results in the endothelial cells releasing a variety of products with inflammatory potential that may attract monocytes and favor their infiltration into the subendothelial space. We have recently shown that human monocytes respond to free arachidonic acid, a well-defined secretory product of activated endothelial cells, by activating the de novo pathway of fatty acid biosynthesis, resulting in the formation of neutral lipids and the acquisition of a foamy phenotye due to the accumulation of cytoplasmic lipid droplets. In this work we describe that the neutral lipids of foamy monocytes are selectively enriched in a rather uncommon fatty acid, cis-7-hexadecenoic acid (16:n-9), a positional isomer of the more frequently described palmitoleic acid, which is strikingly absent from lipid droplets. Experiments addressing the biological role for 16:1n-9 indicate that this fatty acid prevents the inflammatory response of human monocytes and murine macrophages to bacterial lipopolysaccharide both in vitro and in vivo. Collectively, our results provide evidence that a previously unrecognized fatty acid, 16:1n-9, possesses anti-inflammatory activity that is comparable to that of omega-3 fatty acids and is clearly distinguishable from the effects of palmitoleic acid. Moreover, the selective accumulation in the neutral lipids of phagocytic cells of a rather uncommon fatty acid, reveals an early phenotypic change that may provide a biomarker of proatherogenicity, and a potential target for intervention in the early stages of cardiovascular disease.
DescripciónResumen del trabajo presentado presentado al CIBERDEM Annual Meeting, celebrado en Cerdanyola del Vallès, Barcelona (España) del 11 al 13 de mayo de 2016.
URIhttp://hdl.handle.net/10261/160687
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