English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/160383
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Preparation and characterization of maleoylagarose/PNIPAAm graft copolymers and formation of polyelectrolyte complexes with chitosan

AuthorsOrtiz, J. A.; Matsuhiro, B.; Zapata, P. A.; Corrales, Teresa ; Catalina, Fernando
KeywordsMaleoylation
NIPAAm
Graft copolymerization
Hydrogels
Chitosan
Agarose
Issue Date2018
PublisherElsevier
CitationCarbohydrate Polymers 182: 81-91 (2018)
AbstractA water soluble derivative in 98% yield with 23.1% incorporation of maleoyl groups was obtained by esterification of agarose with maleic anhydride. Graft copolymers were synthesized through vinyl groups of maleoylagarose with N-isopropylacrylamide using ceric ammonium nitrate or ammonium persulfate as initiator, by conventional method or microwave irradiation. High nitrogen content (4.6%) was obtained in the grafting process using ceric ammonium nitrate as initiator without microwave irradiation. Copolymers were characterized by FT-IR and NMR spectroscopies, TGA, DSC and morphological analysis by AFM and SEM microscopy, confirming the grafting of PNIPAAm onto polysaccharide backbone. Hydrogel films were obtained by ionic complexation between opposite charged groups of maleoylagarose-g-poly(N-isopropylacrylamide) and chitosan. The swelling of 1:1 w/v maleoylagarose-g-PNIPAAm:chitosan film was higher than 2:1 w/v film at 25 and 37 °C. 53% release in vitro of diclofenac sodium from 1:1 w/v maleoylagarose-g-PNIPAAm:chitosan was obtained at 37 °C and pH 6.0 with <0.5 diffusional constant values.
Publisher version (URL)http://dx.doi.org/10.1016/j.carbpol.2017.11.012
URIhttp://hdl.handle.net/10261/160383
Identifiersdoi: 10.1016/j.carbpol.2017.11.012
issn: 0144-8617
e-issn: 1879-1344
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.