English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/160294
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Protein tyrosine kinases couple the interleukin-2 receptor to p21ras

AuthorsIzquierdo, Manuel ; Cantrell, Doreen A.
Issue Date1993
CitationEuropean Journal of Immunology 23(1): 131-135 (1993)
AbstractThe T cell growth factor interleukin-2 (IL-2) induces p21ras activation in T lymphocytes. We have previously shown that a protein kinase C (PKC)-mediated pathway for p21ras regulation exists in T cells and that the IL-2 receptor (IL-2R) can couple to p21ras independently of the presence of the PKC pathway for p21ras regulation. Our data show that in conditions where cellular protein tyrosine kinases (PTK) were efficiently down-regulated by pretreatment with the specific PTK inhibitor herbimycin, the IL-2-induced activation of p21ras was blocked. Herbimycin did not inhibit the PKC-mediated pathway for p21ras regulation. Thus, the data indicate that PTK are involved in the coupling of the IL-2R to p21ras.
Identifiersdoi: 10.1002/eji.1830230121
issn: 0014-2980
e-issn: 1521-4141
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.