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Title

Protein tyrosine kinases couple the interleukin-2 receptor to p21ras

AuthorsIzquierdo, Manuel ; Cantrell, Doreen A.
Issue Date1993
PublisherWiley-VCH
CitationEuropean Journal of Immunology 23(1): 131-135 (1993)
AbstractThe T cell growth factor interleukin-2 (IL-2) induces p21ras activation in T lymphocytes. We have previously shown that a protein kinase C (PKC)-mediated pathway for p21ras regulation exists in T cells and that the IL-2 receptor (IL-2R) can couple to p21ras independently of the presence of the PKC pathway for p21ras regulation. Our data show that in conditions where cellular protein tyrosine kinases (PTK) were efficiently down-regulated by pretreatment with the specific PTK inhibitor herbimycin, the IL-2-induced activation of p21ras was blocked. Herbimycin did not inhibit the PKC-mediated pathway for p21ras regulation. Thus, the data indicate that PTK are involved in the coupling of the IL-2R to p21ras.
URIhttp://hdl.handle.net/10261/160294
Identifiersdoi: 10.1002/eji.1830230121
issn: 0014-2980
e-issn: 1521-4141
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