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Título

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes

AutorGraves, Jonathan D.; Downward, Julian; Izquierdo, Manuel ; Rayter, Sydonia; Warne, Patricia H.; Cantrell, Doreen A.
Fecha de publicación1992
EditorAmerican Association of Immunologists
CitaciónJournal of Immunology 148(8): 2417-2422 (1992)
ResumenThe T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21ras may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21ras in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21ras may play a role in the regulation of T cell growth by IL-2.
URIhttp://hdl.handle.net/10261/160280
ISSN0022-1767
E-ISSN1550-6606
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