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Title

Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates

AuthorsGrijalvo, Santiago CSIC ORCID; Adagia, Adele; Jorge, Andreia F.; Eritja Casadellà, Ramón CSIC ORCID
KeywordsCovalent approach
Gene delivery
Gen therapy
Non-coding RNA
miRNA technology
RNA interference
Nucleic acid conjugates
Issue Date6-Feb-2018
PublisherMultidisciplinary Digital Publishing Institute
CitationGenes 9(2): 74 (2018)
AbstractOligonucleotide-based therapy has become an alternative to classical approaches in the search of novel therapeutics involving gene-related diseases. Several mechanisms have been described in which demonstrate the pivotal role of oligonucleotide for modulating gene expression. Antisense oligonucleotides (ASOs) and more recently siRNAs and miRNAs have made important contributions either in reducing aberrant protein levels by sequence-specific targeting messenger RNAs (mRNAs) or restoring the anomalous levels of non-coding RNAs (ncRNAs) that are involved in a good number of diseases including cancer. In addition to formulation approaches which have contributed to accelerate the presence of ASOs, siRNAs and miRNAs in clinical trials; the covalent linkage between non-viral vectors and nucleic acids has also added value and opened new perspectives to the development of promising nucleic acid-based therapeutics. This review article is mainly focused on the strategies carried out for covalently modifying siRNA and miRNA molecules. Examples involving cell-penetrating peptides (CPPs), carbohydrates, polymers, lipids and aptamers are discussed for the synthesis of siRNA conjugates whereas in the case of miRNA-based drugs, this review article makes special emphasis in using antagomiRs, locked nucleic acids (LNAs), peptide nucleic acids (PNAs) as well as nanoparticles. The biomedical applications of siRNA and miRNA conjugates are also discussed.
Publisher version (URL)https://doi.org/doi:10.3390/genes9020074
URIhttp://hdl.handle.net/10261/160231
DOIhttp://dx.doi.org/10.3390/genes9020074
Appears in Collections:(IQAC) Artículos
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