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Título

Studies on the formation of O/W nano-emulsions, by low-energy emulsification methods, suitable for pharmaceutical applications

AutorSadurní, Nuria; Solans, Conxita; Azemar Sazatornil, Nuria; García-Celma, M. J.
Palabras claveNano-emulsions
Surfactants
Low-energy emulsification methods
Drug solubilisation
Fecha de publicación8-sep-2005
EditorElsevier
CitaciónEuropean Journal of Pharmaceutical Sciences 26(5): 438-445 (2005)
ResumenThe formation of O/W nano-emulsions suitable for pharmaceutical application and the solubilisation of a practically non-water-soluble drug, lidocaine, have been studied in water/non-ionic surfactant/oil systems. Nano-emulsions were prepared by using low-energy emulsification methods, changing the composition at constant temperature. Kinetic stability was assessed by measuring droplet diameter as a function of time. Lidocaine solubilisation was studied in nano-emulsions with high water content. In the water/Cremophor EL/Miglyol 812 system the lowest droplet sizes, from 14 to 39 nm at 10/90 and 40/60 oil/surfactant ratios, respectively, and 90% of water content, were obtained with an emulsification method consisting of stepwise addition of water to oil/surfactant mixtures at 70 °C. Nano-emulsions of this system showed high kinetic stability. Droplet diameters did not exceed 67 nm after a period of at least 7 months. The maximum lidocaine concentration solubilised in nano-emulsions of the water/Cremophor EL/Miglyol 812 system with 90 and 95% of water content was 3.5 and 2.1%, respectively. These values are within the therapeutic range of lidocaine.
Descripción8 pages, 8 figures, 1 table.-- PMID: 16153811 [PubMed].-- Printed version published Dec 2005.
Versión del editorhttp://dx.doi.org/10.1016/j.ejps.2005.08.001
URIhttp://hdl.handle.net/10261/16022
DOI10.1016/j.ejps.2005.08.001
ISSN0928-0987 (Print)
1879-0720 (Online)
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