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http://hdl.handle.net/10261/160071
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Choircea-Paquim, Ana Maria | es_ES |
dc.contributor.author | Eritja Casadellà, Ramón | es_ES |
dc.contributor.author | Oliveira-Brett, Ana Maria | es_ES |
dc.date.accessioned | 2018-02-02T10:04:17Z | - |
dc.date.available | 2018-02-02T10:04:17Z | - |
dc.date.issued | 2018-01-31 | - |
dc.identifier.citation | Journal of Nucleic Acids (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/160071 | - |
dc.description.abstract | Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology. G-quadruplex electrochemical biosensors have received particular attention, since the electrochemical response is particularly sensitive to the DNA structural changes from single-stranded, double-stranded, or hairpin into a G-quadruplex configuration. Furthermore, the development of an increased number of G-quadruplex aptamers that combine the G-quadruplex stiffness and self-assembling versatility with the aptamer high specificity of binding to a variety of molecular targets allowed the construction of biosensors with increased selectivity and sensitivity. This review discusses the recent advances on the electrochemical characterization, design, and applications of G-quadruplex electrochemical biosensors in the evaluation of metal ions, G-quadruplex ligands, and other small organic molecules, proteins, and cells. The electrochemical and atomic force microscopy characterization of G-quadruplexes is presented. The incubation time and cations concentration dependence in controlling the G-quadruplex folding, stability, and nanostructures formation at carbon electrodes are discussed. Different G-quadruplex electrochemical biosensors design strategies, based on the DNA folding into a G-quadruplex, the use of G-quadruplex aptamers, or the use of hemin/G-quadruplex DNAzymes, are revisited. | es_ES |
dc.description.sponsorship | Financial support from Fundac¸˜ao para a Ciencia e Tecnologia (FCT), Grant SFRH/BPD/92726/2013 (A.-M. Chiorcea- Paquim), Project UID/EMS/00285/2013 (cofinanced by the European Community Fund FEDER), FEDER funds through the program COMPETE, Programa Operacional Factores de Competitividade, and Innovec’EAU (SOE1/P1/F0173) are gratefully acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Hindawi Publishing Corporation | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | DNA | es_ES |
dc.subject | G-Quadruplex Electrochemical Biosensors | es_ES |
dc.subject | DNAzymes | es_ES |
dc.title | Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1155/2018/5307106 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1155/2018/5307106 | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.pmid | 29666699 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
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Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications.pdf | 7,44 MB | Adobe PDF | Visualizar/Abrir |
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