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pH-responsive relaxometric behaviour of coordination polymer nanoparticles made of a stable macrocyclic gadolinium chelate

AuthorsAríñez-Soriano, Javier; Albalad, Jorge ; Carné-Sánchez, Arnau ; Bonnet, Célia S.; Busqué, Félix; Lorenzo, Julia ; Juanhuix, Jordi; Imaz, Inhar ; Tóth, Éva; Maspoch, Daniel
KeywordsContrast agents
Coordination polymers
Issue Date2016
CitationChemistry - A European Journal 22(37): 13162-13170 (2016)
AbstractLanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gdchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r=16.4 mmsat 10 MHz), but also for a pH responsiveness (Δr=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
Identifiersdoi: 10.1002/chem.201602356
e-issn: 1521-3765
issn: 0947-6539
Appears in Collections:(CIN2) Artículos
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