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Title

A Combined Experimental/Computational Study of the Mechanism of a Palladium-Catalyzed Bora-Negishi Reaction

AuthorsCampos, Jesús ; Nova, Ainara; Kolychev, E.L.; Aldridge, Simon
Issue Date2017
PublisherJohn Wiley & Sons
CitationChemistry - A European Journal 23: 12655- 12667 (2017)
AbstractExperimental and computational efforts are reported which illuminate the mechanism of a novel boron version of the widespread Negishi coupling reaction that offers a new protocol for the formation of aryl/acyl C−B bonds using a bulky boryl fragment. The role of nucleophilic borylzinc reagents in the reduction of the Pd pre-catalysts to Pd active species has been demonstrated. The non-innocent behavior of the PPh ligands of the [Pd(PPh)Cl] pre-catalyst under activation conditions has been probed both experimentally and computationally, revealing the formation of a trimetallic Pd species bearing bridging phosphide (PPh ) ligands. Our studies also reveal the monoligated formulation of the Pd active species, which led us to synthesize related (η-indenyl)Pd-monophosphine catalysts which show improved catalytic performances under mild conditions. A complete mechanistic proposal to aid future catalyst developments is provided.
URIhttp://hdl.handle.net/10261/159777
Identifiersdoi: 10.1002/chem.201702703
issn: 1521-3765
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