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Título

Genomic Epidemiology of Tuberculosis

AutorComas, Iñaki
Palabras claveTransmission
Genome sequencing
Outbreak
Mutation rate
Fecha de publicación2017
EditorSpringer Nature
CitaciónStrain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control 4: 79-93 (2017)
SerieAdvances in Experimental Medicine and Biology
1019
ResumenThe application of next generation sequencing technologies has opened the door to a new molecular epidemiology of tuberculosis, in which we can now look at transmission at a resolution not possible before. At the same time, new technical and analytical challenges have appeared, and we are still exploring the wider potential of this new technology. Whole genome sequencing in tuberculosis still requires bacterial cultures. Thus, although whole genome sequencing has revolutionized the interpretation of transmission patterns, it is not yet ready to be applied at the point-of-care. In this chapter, I will review the promises and challenges of genomic epidemiology, as well as some of the new questions that have arisen from the use of this new technology. In addition, I will examine the role of molecular epidemiology within the general frame of global tuberculosis control and how genomic epidemiology can contribute towards the elimination of the disease.
DescripciónGagneux, S. (ed) .-- 16 páginas
Versión del editorhttp://dx.doi.org/ 10.1007/978-3-319-64371-7_4
URIhttp://hdl.handle.net/10261/159480
DOI10.1007/978-3-319-64371-7_4
ISBN978-3-319-64371-7
ISSN0065-2598
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