English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/159409
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorDomínguez-Rodríguez, Pedro-
dc.contributor.authorReina, José J.-
dc.contributor.authorGil-Caballero, Sergio-
dc.contributor.authorNieto, Pedro M.-
dc.contributor.authorPaz, José L. de-
dc.contributor.authorRojo, Javier-
dc.date.accessioned2018-01-22T12:17:46Z-
dc.date.available2018-01-22T12:17:46Z-
dc.date.issued2017-
dc.identifierdoi: 10.1002/chem.201701890-
dc.identifierissn: 1521-3765-
dc.identifier.citationChemistry - A European Journal 23: 11338- 11345 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/159409-
dc.description.abstractChondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The structural complexity of these carbohydrates demands the development of simple glycomimetics as useful tools to study the biological processes where GAGs are involved. In this work we described the synthesis of the disaccharide unit of the CS-E (GlcA-GalNAc(4,6-di-OSO3)), in a multivalent presentation. Using a fluorescence polarization competition assay we have demonstrated that a hexavalent dendrimer of this disaccharide interact with midkine, in the low micromolar range. This result highlights the potency of these disaccharide-displaying multivalent systems as interesting mimetics of longer and synthetically more complex GAG oligosaccharides.-
dc.publisherJohn Wiley & Sons-
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_EN
dc.titleGlycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine-
dc.typeArtículo-
dc.embargo.terms2018-08-03-
dc.date.updated2018-01-22T12:17:46Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.relation.csic-
Appears in Collections:(EBD) Artículos
Files in This Item:
File Description SizeFormat 
CEJ 2017-ms4 Revised Version-def.pdf934,68 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.