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http://hdl.handle.net/10261/159265
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Izquierdo, Manuel | es_ES |
dc.contributor.author | Grandien, A. | - |
dc.contributor.author | Criado, Luis M. | - |
dc.contributor.author | Robles, S. | - |
dc.contributor.author | Leonardo, Esther | - |
dc.contributor.author | Albar, Juan Pablo | - |
dc.contributor.author | González de Buitrago, Gonzalo | - |
dc.contributor.author | Martínez-Alonso, Carlos | - |
dc.date.accessioned | 2018-01-18T11:21:19Z | - |
dc.date.available | 2018-01-18T11:21:19Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | EMBO Journal 18(1): 156-166 (1999) | es_ES |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10261/159265 | - |
dc.description.abstract | Clonal deletion in the thymus by apoptosis is involved in purging the immune system of self‐reactive T lymphocytes (negative selection). Cysteine proteases (caspases) belonging to the CPP32 family are activated during this process. We have produced transgenic mice expressing baculovirus p35, a broad‐range caspase inhibitor. Thymocytes from p35 transgenic mice were resistant in vitro to several apoptosis‐inducing agents; this resistance correlated with the inhibition of CPP32‐like activity. Negative selection in vivo of thymocytes triggered by two exogenous antigens, staphylococcal enterotoxin B superantigen and an antigenic peptide in the F5 T‐cell receptor transgenic model, was specifically inhibited in p35 transgenic mice. Our results provide direct evidence for caspase involvement in negative selection during thymocyte development. | es_ES |
dc.description.sponsorship | M.S.R. receives a fellowship from Pharmacia & Upjohn. A.G. is supported by grants from the Swedish Medical Research Council (06P‐118, 16X‐12215). This work was supported in part by grants from the Spanish DGICyT. The Department of Immunology and Oncology was founded and is supported by the Spanish Research Council (CSIC) and Pharmacia & Upjohn. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | European Molecular Biology Organization | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Baculovirus p35 | es_ES |
dc.subject | Caspases | - |
dc.subject | Negative selection | - |
dc.subject | Thymocytes | - |
dc.title | Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1093/emboj/18.1.156 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1093/emboj/18.1.156 | es_ES |
dc.identifier.e-issn | 1460-2075 | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Swedish Research Council | - |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.pmid | 9878059 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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