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dc.contributor.authorIzquierdo, Manueles_ES
dc.contributor.authorGrandien, A.-
dc.contributor.authorCriado, Luis M.-
dc.contributor.authorRobles, S.-
dc.contributor.authorLeonardo, Esther-
dc.contributor.authorAlbar, Juan Pablo-
dc.contributor.authorGonzález de Buitrago, Gonzalo-
dc.contributor.authorMartínez-Alonso, Carlos-
dc.date.accessioned2018-01-18T11:21:19Z-
dc.date.available2018-01-18T11:21:19Z-
dc.date.issued1999-
dc.identifier.citationEMBO Journal 18(1): 156-166 (1999)es_ES
dc.identifier.issn0261-4189-
dc.identifier.urihttp://hdl.handle.net/10261/159265-
dc.description.abstractClonal deletion in the thymus by apoptosis is involved in purging the immune system of self‐reactive T lymphocytes (negative selection). Cysteine proteases (caspases) belonging to the CPP32 family are activated during this process. We have produced transgenic mice expressing baculovirus p35, a broad‐range caspase inhibitor. Thymocytes from p35 transgenic mice were resistant in vitro to several apoptosis‐inducing agents; this resistance correlated with the inhibition of CPP32‐like activity. Negative selection in vivo of thymocytes triggered by two exogenous antigens, staphylococcal enterotoxin B superantigen and an antigenic peptide in the F5 T‐cell receptor transgenic model, was specifically inhibited in p35 transgenic mice. Our results provide direct evidence for caspase involvement in negative selection during thymocyte development.es_ES
dc.description.sponsorshipM.S.R. receives a fellowship from Pharmacia & Upjohn. A.G. is supported by grants from the Swedish Medical Research Council (06P‐118, 16X‐12215). This work was supported in part by grants from the Spanish DGICyT. The Department of Immunology and Oncology was founded and is supported by the Spanish Research Council (CSIC) and Pharmacia & Upjohn.es_ES
dc.language.isoenges_ES
dc.publisherEuropean Molecular Biology Organizationes_ES
dc.rightsclosedAccesses_ES
dc.subjectBaculovirus p35es_ES
dc.subjectCaspases-
dc.subjectNegative selection-
dc.subjectThymocytes-
dc.titleBlocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitores_ES
dc.typeartículoes_ES
dc.identifier.doi10.1093/emboj/18.1.156-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1093/emboj/18.1.156es_ES
dc.identifier.e-issn1460-2075-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderSwedish Research Council-
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.pmid9878059-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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