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Title

From bioavailability science to regulation of organic chemicals: a communication experiment

AuthorsOrtega Calvo, J. J. ; Harmsen, J.; Parsons, J. R.; Römbke, J.; Semple, Kirk T.
Issue Date22-May-2016
PublisherSociety of Environmental Toxicology and Chemistry
CitationSETAC Europe 26th Annual Meeting. "Environmental contaminants from land to sea: continuities and interface in environmental toxicology and chemistry"22-26 May 2016, Nantes, France
AbstractThe bioavailability of organic chemicals (i.e., mainly industrial chemicals, pesticides, biocides and pharmaceuticals) in soil and sediment is an important area of scientific research. However, this area remains only partially recognized by regulators and industries working in the environmental sector. Based on the positive experiences already made with metals, regulators have recently started to consider bioavailability within retrospective risk assessment (RA) frameworks (e.g. of contaminated sites) for organic chemicals. By doing so, realistic decision-making in terms of hazard definition and priority considerations finally resulting in optimised cost allocation can be achieved, rather than relying on the established approach of using total-extractable concentrations. However, implementation of biovailability remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators and, therefore, no integrated approach for implementation is available. For the same reason, bioavailability remains largely unexplored within prospective regulatory frameworks (e.g. REACH) that address the approval and regulation of organic chemicals. To facilitate the inclusion of bioavailability within more realistic RA frameworks, agreement and common understanding between scientists and regulators is required. This contribution has been prepared by the five proposing authors that represent a bigger group of authors from academia, industry and regulation, who have recently arrived at an agreement and discussed bioavailability concepts and methods. In addition, we offer a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment. A key motivation for this communication exercise was the differences between scientific and regulatory perception. The developments achieved at the Special Science Symposium focused on bioavailability, organized in 2014 by SETAC Europe (http://sesss10.setac.eu/), subsequently led to a featured paper (Environ. Sci. Technol. 49:10255-10264, 2015). In the paper, we propose a simplified approach in which the assessments of soil/sediment and the target chemicals should be based on two measurable values: the total extractable concentration, and the bioavailable concentration as measured with robust and reproducible chemical and/or biological methods (desorption extraction, passive sampling, aqueous extraction, and/or biological tests).
DescriptionPóster presentado en SETAC Europe 26th Annual Meeting. "Environmental contaminants from land to sea: continuities and interface in environmental toxicology and chemistry"22-26 May 2016, Nantes, France
URIhttp://hdl.handle.net/10261/159019
Appears in Collections:(IRNAS) Comunicaciones congresos
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