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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | González, M. E. | - |
dc.contributor.author | Martínez-Abarca, Francisco | - |
dc.contributor.author | Carrasco, Luís | - |
dc.date.accessioned | 2018-01-11T11:50:41Z | - |
dc.date.available | 2018-01-11T11:50:41Z | - |
dc.date.issued | 1990 | - |
dc.identifier | issn: 0956-3202 | - |
dc.identifier.citation | Antiviral Chemistry and Chemotherapy 1: 203- 209 (1990) | - |
dc.identifier.uri | http://hdl.handle.net/10261/158999 | - |
dc.description.abstract | Some naturally occurring flavonoids, such as 3-methyl quercetin and Ro-090179, show potent anti-picornavirus activity. They inhibit poliovirus replication at concentrations 100-fold or 1000-fold lower than hy- droxybenzyl-benzimidazole (HBB) and guanidine, re- spectively. Ro-090179 selectively blocks viral RNA synthesis in poliovirus-infected HeLa cells more strongly than 3-methyl quercetin and is therefore the most potent and selective inhibitor of poliovirus RNA synthesisdescribed until now. In addition, Ro-090179 discriminates in its inhibition between plus and minus-stranded RNA synthesis. Thus, analysis of the viral RNA made in poliovirus-infected cells when the compound is added late in the infection cycle, indi- cates that the synthesis of genomic RNA is potently blocked, whereas minus-stranded RNA synthesis is not inhibited. These findings make Ro-090179 a valu- able compound for obtaining insight into the molecular mechanisms of poliovirus RNA replication | - |
dc.description.sponsorship | Fundación Ramón Areces | - |
dc.publisher | Blackwell Publishing | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | - |
dc.title | Flavonoids: potent inhibitors of poliovirus RNA synthesis | - |
dc.type | artículo | - |
dc.date.updated | 2018-01-11T11:50:41Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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