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Mode of action of a new type of UDP-glucose analog against herpesvirus replication

AuthorsAlarcón, Balbino ; González, M. E.; Carrasco, Luís; Méndez-Castrillon, Paloma P.; García-López, M. Teresa ; De las Heras, Federico G.
Issue Date1988
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 32: 1257- 1261 (1988)
AbstractThe mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 μg/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 μg/ml it had no cytotoxic effects, as evidence by phase-contrast microscopy. P-536 showed a wide spectrum of action and was active against HSV-1, adenovirus type 5, vaccinia virus, poliovirus type 1, encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and measles virus, irrespective of whether these viruses have lipidic envelopes or not. P-536 clearly inhibited protein glycosylation if added at the time when late viral proteins were being synthesized. Moreover, it also interfered with the synthesis of nucleic acids and the phosphorylation of nucleosides. If P-536 was present from the beginning of infection, HSV-1 replication was blocked at an early step and the infected cells continued to synthesize cellular proteins for long periods.
Identifiersissn: 0066-4804
Appears in Collections:(CBM) Artículos
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