English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/158939
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks

AutorPerea, Gertrudis ; Gómez, R.; Mederos, S.; Covelo, A.; Ballesteros, J. J.; Schlosser, L.; Hernández-Vivanco, A.; Martín-Fernández, Mario; Quintana, R.; Rayan, A.; Díez, A.; Fuenzalida, M.; Agarwal, A.; Bergles, D. E.; Bettler, B.; Manahan-Vaughan, D.; Martín, E. D.; Kirchhoff, F.; Araque, Alfonso
Palabras claveneuron-glia interactions
interneuron
Astrocytes
neuroscience
rat
synaptic plasticity
mouse
Fecha de publicación2016
EditoreLife Sciences Publications
CitacióneLife 5 (2016)
ResumenInterneurons are critical for proper neural network function and can activate Ca2 signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown. Using the simplest hippocampal Astrocyte-Neuron network, i.e., GABAergic interneuron, pyramidal neuron, single CA3-CA1 glutamatergic synapse, and astrocytes, we found that interneuron-astrocyte signaling dynamically affected excitatory neurotransmission in an activity- and time-dependent manner, and determined the sign (inhibition vs potentiation) of the GABA-mediated effects. While synaptic inhibition was mediated by GABAA receptors, potentiation involved astrocyte GABAB receptors, astrocytic glutamate release, and presynaptic metabotropic glutamate receptors. Using conditional astrocyte-specific GABAB receptor (Gabbr1) knockout mice, we confirmed the glial source of the interneuron-induced potentiation, and demonstrated the involvement of astrocytes in hippocampal theta and gamma oscillations in vivo. Therefore, astrocytes decode interneuron activity and transform inhibitory into excitatory signals, contributing to the emergence of novel network properties resulting from the interneuron-astrocyte interplay.
URIhttp://hdl.handle.net/10261/158939
Identificadoresdoi: 10.7554/eLife.20362
issn: 2050-084X
Aparece en las colecciones: (IC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
elife 2016.pdf4,33 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.