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dc.contributor.author | Fredduzzi, S. | - |
dc.contributor.author | Moratalla, Rosario | - |
dc.contributor.author | Monopoli, A. | - |
dc.contributor.author | Cuéllar, Beatriz | - |
dc.contributor.author | Xu, K. | - |
dc.contributor.author | Ongini, E. | - |
dc.contributor.author | Impagnatiello, F. | - |
dc.contributor.author | Schwarzschild, M.A. | - |
dc.contributor.author | Chen, J.-F. | - |
dc.date.accessioned | 2017-12-22T12:31:10Z | - |
dc.date.available | 2017-12-22T12:31:10Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Neuroscience 22: 1054- 1062 (2002) | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10261/158532 | - |
dc.description.abstract | To investigate the role of A2A adenosine receptors in adaptive responses to chronic intermittent dopamine receptor stimulation, we compared the behavioral sensitization elicited by repeated L-DOPA treatment in hemiparkinsonian wild-type (WT) and A2A adenosine receptor knock-out (A2A KO) mice. Although the unilateral nigrostriatal lesion produced by intrastriatal injection of 6-hydroxydopamine was indistinguishable between WT and A2A KO mice, they developed strikingly different patterns of behavioral sensitization after daily treatment with low doses of L-DOPA for 3 weeks. WT mice initially displayed modest contralateral rotational responses and then developed progressively greater responses that reached a maximum within 1 week and persisted for the duration of the treatment. In contrast, any rotational behavioral sensitization in A2A KO mice was transient and completely reversed within 2 weeks. Similarly, the time to reach the peak rotation was progressively shortened in WT mice but remained unchanged in A2A KO mice. Furthermore, daily L-DOPA treatment produced gradually sensitized grooming in WT mice but failed to induce any sensitized grooming in A2A KO mice. Finally, repeated L-DOPA treatment reversed the 6-OHDA-induced reduction of striatal dynorphin mRNA in WT but not A2A KO mice, raising the possibility that the A2A receptor may contribute to L-DOPA-induced behavioral sensitization by facilitating adaptations within the dynorphin-expressing striatonigral pathway. Together these results demonstrate that the A2A receptor plays a critical role in the development and particularly the persistence of behavioral sensitization to repeated L-DOPA treatment. Furthermore, they raise the possibility that the maladaptive dyskinetic responses to chronic L-DOPA treatment in Parkinson's disease may be attenuated by A2A receptor inactivation. | - |
dc.publisher | Society for Neuroscience | - |
dc.rights | openAccess | - |
dc.subject | dynorphin | - |
dc.subject | dyskinesia | - |
dc.subject | Parkinson's disease | - |
dc.subject | Behavioral sensitization | - |
dc.subject | l-DOPA | - |
dc.subject | A2A adenosine receptor | - |
dc.title | Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1523/JNEUROSCI.22-03-01054.2002 | - |
dc.date.updated | 2017-12-22T12:31:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.identifier.pmid | 11826134 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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