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Computer Tomography for avoiding fractures, controlling ice and monitoring cryoprotectant in organ cryopreservation

AuthorsRisco, Ramón; Corral, Ariadna; Parrado-Gallego, Ángel; Balcerzyk, Marcin
Issue Date2015
CitationCryobiology 71(1): 175 (2015)
AbstractFrom an engineering point of view, the challenge of organ cryopreservation is a problem of heat and mass transfer. However, from a technical point of view, there are four major goals: avoiding fractures, controlling ice, monitoring the cryoprotectant concentration and having a fast and uniform rewarming. Computer Tomography (CT) can help at least with the first three of these four topics; in the case of DMSO based cryoprotectant, the high number of electrons in the sulfur atom of this molecule makes it visible at energies around 70 KeV, where the photoelectric effect is dominant. Water, DMSO and air (fractures) have very different CT values, offering the possibility of drawing a 3D map of the status of the organ not only after the cryopreservation, but also during the loading and/or cooling steps. Kidneys and cryopreserved ovarian tissue have been monitored with a nanoCT. A spectacle of patterns and structures is revealed under the light of the X-rays.
DescriptionAbstract presented at the Organ Preservation Alliance’s Organ Banking Summit, held February 26–28, 2015, Silicon Valley, California, USA.
Publisher version (URL)https://doi.org/10.1016/j.cryobiol.2015.05.045
Identifiersdoi: 10.1016/j.cryobiol.2015.05.045
issn: 0011-2240
e-issn: 1090-2392
Appears in Collections:(CNA) Artículos
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