English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/158279
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The elemental role of iron in DNA synthesis and repair

AuthorsPuig, Sergi ; Ramos Alonso, Lucía ; Romero, Antonia ; Martínez Pastor, M. Teresa
KeywordsIron cofactor
Iron-sulfur cluster
DNA synthesis
DNA repair
Yeast
Saccharomyces cerevisiae
Iron deficiency
Ribonucleotide reductase
Issue Date31-Aug-2017
PublisherRoyal Society of Chemistry (UK)
CitationMetallomics 9 (11): 1483-1500 (2017)
AbstractIron is an essential redox element that functions as a cofactor in many metabolic pathways. Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase, use iron as an indispensable cofactor to function. Recent striking results have revealed that the catalytic subunit of DNA polymerases also contains conserved cysteine-rich motifs that bind iron–sulfur (Fe/S) clusters that are essential for the formation of stable and active complexes. In line with this, mitochondrial and cytoplasmic defects in Fe/S cluster biogenesis and insertion into the nuclear iron-requiring enzymes involved in DNA synthesis and repair lead to DNA damage and genome instability. Recent studies have shown that yeast cells possess multi-layered mechanisms that regulate the ribonucleotide reductase function in response to fluctuations in iron bioavailability to maintain optimal deoxyribonucleotide concentrations. Finally, a fascinating DNA charge transport model indicates how the redox active Fe/S centers present in DNA repair machinery components are critical for detecting and repairing DNA mismatches along the genome by long-range charge transfers through double-stranded DNA. These unexpected connections between iron and DNA replication and repair have to be considered to properly understand cancer, aging and other DNA-related diseases.
Publisher version (URL)http://dx.doi.org/10.1039/c7mt00116a
URIhttp://hdl.handle.net/10261/158279
DOI10.1039/c7mt00116a
E-ISSN1756-591X
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Metallomics-2017-Puig.pdfArtículo principal3,75 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.