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Title

Mass spectrometry-based lipidomic approaches to identify lipid markers of inflammation

AuthorsBalsinde, Jesús
Issue Date2016
CitationPrograma de Pós-Graduaçâo em Imunologia Básica e Aplicada (2016)
AbstractMass spectrometry (MS) in combination with liquid chromatography (LC), or LC/MS, is the preferred technique for lipidomic analyses. One of the most used applications of lipidomics is the search for molecular markers that can be used to signal specific activation states and that, ultimately, can be used in the early diagnosis of diseases. Our recent studies with monocytes/macrophages stimulated by inflammatory stimuli have revealed changes that result in the accumulation of unusual lipids. These changes are sometimes stimulus-specific and thus, could be regarded as specific markers of activation. Two examples are discussed below that resulted from the lipidomic analysis of arachidonate-containing phospholipids, and the analysis of the fatty acid composition of neutral lipids accumulating in cytoplasmic lipid droplets.
DescriptionTranscription of the talk presented on Thursday October 27, 2016 at the Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (Brazil).
URIhttp://hdl.handle.net/10261/158215
Appears in Collections:(IBGM) Comunicaciones congresos
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