English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/158204
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Rho GTPases and their regulators in addiction: A focus on the association of a ß2-chimaerin polymorphism with smoking

AuthorsCaloca, María J. ; Barrio, Laura del; González-Sarmiento, Rogelio
Single nucleotide polymorphism
Rho GTPase
Nicotine addiction
GTPase activating protein
Synaptic plasticity
Issue Date2016
CitationNeuropathology of Drug Addictions and Substance Misuse: 125-132 (2016)
SeriesFoundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids 1
AbstractTobacco addiction is a complex disorder that involves multiple molecular mechanisms and is influenced by genetic factors. Repeated exposure to nicotine induces the remodeling of synaptic connections, a process that contributes to the long-lasting nature of tobacco addiction. Rho GTPases are key regulators of synaptic structure and function and, therefore, these proteins have a potential role in nicotine addiction. In this chapter we will briefly describe some studies that identify genes encoding Rho GTPases and their regulators as candidate genes for smoking-related behaviors, with special focus on the CHN2 gene. The CHN2 gene encodes the β2-chimaerin, a member of the chimaerin family of GTPase activating proteins that selectively inactivates the GTPase Rac. Genetic studies suggest that nucleotide variants of the CHN2 gene may influence success in smoking cessation. In addition, work has identified a significant association of the rs186911567 polymorphism in the CHN2 gene with smoking in a Spanish population. We discuss how this polymorphism could alter β2-chimaerin function and the signaling pathways mediated by this protein that could influence smoking behavior.
Identifiersdoi: 10.1016/B978-0-12-800213-1.00012-2
isbn: 978-0-12-800213-1
Appears in Collections:(IBMCC) Libros y partes de libros
(IBGM) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.