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Title

BDNF-dependent auditory fibers enhance fidelity of auditory information processing within the ascending auditory pathway

AuthorsKnipper, Marlies; Chumak, Tetyana; Rüttiger, Lukas; Lee, Sze Chim; Zuccotti, Annalisa; Singer, Wibke; Gutsche, Katja; Schimmang, Thomas ; Zimmermann, Ulrike
Issue Date2015
CitationARO MidWinter Meeting (2015)
AbstractThe accomplishment of spatial and temporal cortical resolution in the central auditory system is a process that is assumed to be initiated by the first auditory experience. Experience driven activity has been suggested to trigger increased intrinsic inhibition towards shaping the central sound resolution in dependency of brain-derived neurotrophic factor (BDNF). The experience dependent driving force for this process has so far not been specified further. Using mice with conditional deletion of BDNF under the Pax2 promotor and the TrkC promotor, we here demonstrate that the deletion of BDNF in the cochlea (BDNFPax2-KO) but not in the auditory cortex (BDNFTrkC-KO) or the inferior colliculus (BDNFPax2-KO, BDNFTrkC-KO) severely reduced dynamic range of sound sensitivity and noise vulnerability. Extracellular sound-evoked responses from IC neurons in BDNFPax2-WT and BDNFPax2-KO mice before and after acoustic trauma, moreover revealed that a BDNF dependent auditory fiber activity drives short response latency, low sound thresholds, and the narrow tuning of IC neurons including the generation regulatory high-frequency inhibitory sidebands. Analysis of further characteristic features within the ascending pathway of the mice mutants suggests that driving force for BDNF dependent intracortical inhibition itself may be a BDNF dependent process. The loss of the BDNF dependent intracortical inhibition has severe consequences for central sound processing. Data are discussed in the context of a novel role of cochlear BDNF for auditory processing and central auditory plasticity.
DescriptionResumen del póster presentado al 38th Annual MidWinter Meeting of the Association for Research in Otolaryngology, celebrado en Baltimore, Maryland (US) del 20 al 25 de febrero de 2015.-- et al.
URIhttp://hdl.handle.net/10261/158181
Appears in Collections:(IBGM) Comunicaciones congresos
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