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Title

Remodeling of calcium entry pathways in cancer

AuthorsVillalobos, Carlos ; Sobradillo, Diego ; Hernández-Morales, Miriam ; Núñez, Lucía
KeywordsAspirin
NSAID
Cancer
Colorectal cancer
Store-operated Ca2+ entry
Issue Date2016
PublisherSpringer Nature
CitationCalcium Entry Pathways in Non-excitable Cells: 449-466 (2016)
SeriesAdvances in Experimental Medicine and Biology 898
AbstractCa(2+) entry pathways play important roles in control of many cellular functions, including long-term proliferation, migration and cell death. In recent years, it is becoming increasingly clear that, in some types of tumors, remodeling of Ca(2+) entry pathways could contribute to cancer hallmarks such as excessive proliferation, cell migration and invasion as well as resistance to cell death or survival. In this chapter we briefly review findings related to remodeling of Ca(2+) entry pathways in cancer with emphasis on the mechanisms that contribute to increased store-operated Ca(2+) entry (SOCE) and store-operated currents (SOCs) in colorectal cancer cells. Finally, since SOCE appears critically involved in colon tumorogenesis, the inhibition of SOCE by aspirin and other NSAIDs and its possible contribution to colon cancer chemoprevention is reviewed.
URIhttp://hdl.handle.net/10261/158094
DOI10.1007/978-3-319-26974-0_19
Identifiersdoi: 10.1007/978-3-319-26974-0_19
isbn: 978-3-319-26972-6
Appears in Collections:(IBGM) Libros y partes de libros
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