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Título

Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells

AutorTouriño, Sonia; Selga, Ariadna; Jiménez, Aurora; Juliá, Lluís; Lozano, Carles; Lizárraga, Daneida; Cascante, Marta; Torres, Josep Lluís
Palabras clavePinus pinaster
Polyphenols
Procyanidins
Catechins
Antioxidants
Free radical scavenging activity
Emulsions
Cell proliferation
Fecha de publicación30-abr-2005
EditorAmerican Chemical Society
CitaciónJournal of Agricultural and Food Chemistry 53(12): 4728–4735 (2005)
ResumenPine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection.
Descripción8 pages, 3 figures, 1 scheme, 3 tables.-- PMID: 15941307 [PubMed].-- Printed version published Jun 15, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jf050262q
Versión del editorhttp://dx.doi.org/10.1021/jf050262q
URIhttp://hdl.handle.net/10261/15809
DOI10.1021/jf050262q
ISSN0021-8561 (Print)
1520-5118 (Online)
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