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Phthalimide-derived strigolactone mimics as germinating agents for seeds of parasitic weeds

AuthorsCala, Antonio; Ghooray, Kala; Fernández-Aparicio, Mónica ; Molinillo, José M. G.; Galindo, Juan C. G.; Rubiales, Diego ; Macías, Francisco A.
Seed germination
Issue DateNov-2016
PublisherJohn Wiley & Sons
CitationPest Management Science 72(11): 2069-2081 (2016)
Abstract[Background] Broomrapes attack important crops, cause severe yield losses and are difficult to eliminate because their seed bank is virtually indestructible. In the absence of a host, the induction of seed germination leads to inevitable death due to nutrient starvation. Synthetic analogues of germination-inducing factors may constitute a cheap and feasible strategy to control the seed bank. These compounds should be easy and cheap to synthesise, as this will allow their mass production. The aim of this work is to obtain new synthethic germinating agents.
[Results] Nineteen N-substituted phthalimides containing a butenolide ring and different substituents in the aromatic ring were synthesised. The synthesis started with commercially available phthalimides. The complete collection was assayed against the parasitic weeds Orobanche minor, O. cumana, Phelipanche ramosa and P. aegyptiaca, with the synthetic strigolactone analogue GR24 used as a positive control. These compounds offered low EC50 values: O. cumana 38.3 μM, O. minor 3.77 μM, P. aegyptiaca 1.35 μM and P. ramosa 1.49 μM.
[Conclusions] The synthesis was carried out in a few steps and provided the target compounds in good yields. The compounds tested showed great selectivity, and low EC50 values were obtained for structures that were simpler than GR24. © 2016 Society of Chemical Industry
Publisher version (URL)http://doi.org/10.1002/ps.4323
Appears in Collections:(IAS) Artículos
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