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Effects of Cyclodextrin Glycosiltranferase Modified Starch and Alfa and Beta Cyclodextrins on Plasma Glucose and Lipids Metabolism in Mice

AuthorsDurá, Ángela ; Yokoyama, W.; Rosell, Cristina M.
Metabolic effect
Issue Date16-May-2017
PublisherJSciMed Central
CitationJournal of Drug Design and Research 4 (5): 1051 (2017)
AbstractThe potential functional and nutritional benefits of granular starch treated with cyclodextrin glycosyltransferase (CGTase) and the released cyclodextrins (CDs) were explored in in vivo studies. The metabolic effects of diets in the C57BL/6J mouse containing native and enzymatically modified corn starch by CGTase with or without hydrolysis products were studied. The hydrolysis products were oligosaccharides and CDs, mainly b-CD. Blood glucose concentration at 2 hours was higher suggesting that enzymatically treated starches containing CDs slowed digestion resulting in a longer period of absorption and consequently higher blood glucose levels at the later times. The modified starch with CDs tended to increase HDL-cholesterol levels while decreasing VLDL-cholesterol levels. The CGTase modified starches lowered total and cholesterol ester values in liver and decreased fecal fat extraction. The inclusion of CGTase modified granular starches in the presence of their hydrolysis products may be useful to prevent obesity and other related metabolic diseases, offering an alternative healthy ingredient to the food industry.
Publisher version (URL)https://www.jscimedcentral.com/DrugDesign/drugdesign-4-1051.pdf
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