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Título

Temporal and spatial expression of CCN3 during retina development

AutorLaurent, Maryvonne; Dréau, G. le ; Guillonneau, Xavier; Lelièvre, Elise; Slembrouck, Amélie; Goureau, Olivier; Martinerie, Cécile; Marx, Maria
Fecha de publicación2012
EditorJohn Wiley & Sons
CitaciónDevelopmental Neurobiology 72(11): 1363-1375 (2012)
ResumenNOV/CCN3 is one of the founding members of the CCN (Cyr61 CTGF NOV) family. In the avian retina, CCN3 expression is mostly located within the central region of the inner nuclear layer. As retinal development progresses and this retinal layer differentiates and matures, CCN3 expression forms a dorsal–ventral and a central–peripheral gradient. CCN3 is produced by two glial cell types, peripapillary cells and Müller cells, as well as by horizontal, amacrine, and bipolar interneurons. In retinal neurons and Müller cell cultures, CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Müller cells and has no effect in retinal neurons. In Müller cells, the CCN3 expression detected may thus result from a balance between the Notch and BMP signaling pathways. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2012
Versión del editorhttps://www.doi.org/10.1002/dneu.20994
URIhttp://hdl.handle.net/10261/157987
DOI10.1002/dneu.20994
Identificadoresdoi: 10.1002/dneu.20994
issn: 1932-8451
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