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dc.contributor.authorHaro, Carmenes_ES
dc.contributor.authorLanda, Blanca B.es_ES
dc.contributor.authorNavas Cortés, Juan Antonioes_ES
dc.contributor.authorCamargo, Antonioes_ES
dc.date.accessioned2017-12-04T09:47:20Z-
dc.date.available2017-12-04T09:47:20Z-
dc.date.issued2016-05-26-
dc.identifier.citationPLoS ONE 11(5): e0154090 (2016)es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10261/157945-
dc.descriptionHaro, Carmen et al.es_ES
dc.description.abstractIntestinal microbiota changes are associated with the development of obesity. However, studies in humans have generated conflicting results due to high inter-individual heterogeneity in terms of diet, age, and hormonal factors, and the largely unexplored influence of gender. In this work, we aimed to identify differential gut microbiota signatures associated with obesity, as a function of gender and changes in body mass index (BMI). Differences in the bacterial community structure were analyzed by 16S sequencing in 39 men and 36 post-menopausal women, who had similar dietary background, matched by age and stratified according to the BMI. We observed that the abundance of the Bacteroides genus was lower in men than in women (P<0.001, Q = 0.002) when BMI was > 33. In fact, the abundance of this genus decreased in men with an increase in BMI (P<0.001, Q<0.001). However, in women, it remained unchanged within the different ranges of BMI. We observed a higher presence of Veillonella (84.6% vs. 47.2%; X2 test P = 0.001, Q = 0.019) and Methanobrevibacter genera (84.6% vs. 47.2%; X2 test P = 0.002, Q = 0.026) in fecal samples in men compared to women. We also observed that the abundance of Bilophila was lower in men compared to women regardless of BMI (P = 0.002, Q = 0.041). Additionally, after correcting for age and sex, 66 bacterial taxa at the genus level were found to be associated with BMI and plasma lipids. Microbiota explained at P = 0.001, 31.17% variation in BMI, 29.04% in triglycerides, 33.70% in high-density lipoproteins, 46.86% in low-density lipoproteins, and 28.55% in total cholesterol. Our results suggest that gut microbiota may differ between men and women, and that these differences may be influenced by the grade of obesity. The divergence in gut microbiota observed between men and women might have a dominant role in the definition of gender differences in the prevalence of metabolic and intestinal inflammatory diseases.es_ES
dc.description.sponsorshipThe CORDIOPREV study is supported by the Fundación Patrimonio Comunal Olivarero, Junta de Andalucía (Consejería de Salud, Consejería de Agricultura y Pesca, Consejería de Innovación, Ciencia y Empresa), Diputaciones de Jaén y Córdoba, Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud, and Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de España. It was also partly supported by research grants from the Ministerio de Ciencia e Innovacion (AGL2009-122270 to J LM, FIS PI10/01041 to P P-M; PI10/02412 to F P-J); Ministerio de Economía y Competitividad (AGL2012/39615, PIE14/00005, and PIE 14/00031 to J L-M; FIS PI13/00023 to J D-L, PI13/00619 to F P-J; CP14/00114 to A C); Consejería de Innovación, Ciencia y Empresa, Proyectos de Investigación de Excelencia, Junta de Andalucía (CTS-5015 to F P-J; CVI-7450 to J L-M;); Consejeria de Salud, Junta de Andalucia (PI0193/09 to J L-M, PI-0252/09 to J D-L, and PI-0058/10 to P P-M); and Fondo Europeo de Desarrollo Regional (FEDER). Antonio Camargo is supported by an ISCIII research contract (Programa Miguel-Servet CP14/00114). Juan F. Alcalá-Díaz is supported by an SCIII research contract (Programa Rio-Hortega).es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleIntestinal Microbiota Is Influenced by Gender and Body Mass Indexes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0154090-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1371/journal.pone.0154090es_ES
dc.rights.licensehttps://creativecommons.org/publicdomain/zero/1.0/es_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderFundación Patrimonio Comunal Olivareroes_ES
dc.contributor.funderDiputación de Córdobaes_ES
dc.contributor.funderDiputación de Jaénes_ES
dc.contributor.funderMinisterio de Medio Ambiente y Medio Rural y Marino (España)es_ES
dc.contributor.funderFundación Centro de Excelencia en Investigación Sobre Aceite de Oliva y Saludes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100014211es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.identifier.pmid27228093-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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