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Title

New aminocyclitols as modulators of glucosylceramide metabolism

AuthorsEgido-Gabás, Meritxell; Serrano, Pedro; Casas Brugulat, Josefina; Llebaria, Amadeu; Delgado Cirilo, Antonio
KeywordsAminocyclitol
Glucosylceramide metabolism
N-alkyl
Inhibitors
Therapeutic applications
Issue Date1-Mar-2005
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 3(7): 1195-1201 (2005)
AbstractA series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure–activity relationships is provided
Description7 pages, 3 figures, 4 schemes, 1 table.-- PMID: 15785807 [PubMed].-- Printed version published Mar 2005.
Publisher version (URL)http://dx.doi.org/10.1039/b411473f
URIhttp://hdl.handle.net/10261/15788
DOI10.1039/b411473f
ISSN1477-0520
E-ISSN1477-0539
Appears in Collections:(IQAC) Artículos
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