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dc.contributor.authorGuijas, Carlos-
dc.contributor.authorMeana, Clara-
dc.contributor.authorAstudillo, Alma M.-
dc.contributor.authorBalboa, María A.-
dc.contributor.authorBalsinde, Jesús-
dc.date.accessioned2017-11-28T11:08:02Z-
dc.date.available2017-11-28T11:08:02Z-
dc.date.issued2016-
dc.identifierdoi: 10.1016/j.chembiol.2016.04.012-
dc.identifierissn: 2451-9456-
dc.identifier.citationCell Chemical Biology 23(6): 689-699 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/157795-
dc.description.abstractHuman monocytes respond to arachidonic acid, a secretory product of endothelial cells, by activating the de novo pathway of fatty acid biosynthesis, resulting in the acquisition of a foamy phenotype due to accumulation of cytoplasmic lipid droplets. Recruitment of foamy monocytes to endothelium is a key step in the formation of atherosclerotic plaques. Here we describe that lipid droplets of foamy monocytes are enriched in a rather uncommon fatty acid, cis-7-hexadecenoic acid (16:1n-9), a positional isomer of palmitoleic acid. 16:1n-9 was found to possess an anti-inflammatory activity both in vitro and in vivo that is comparable with that of omega-3 fatty acids and clearly distinguishable from the effects of palmitoleic acid. Selective accumulation in neutral lipids of phagocytic cells of an uncommon fatty acid reveals an early phenotypic change that may provide a biomarker of proatherogenicity, and a potential target for intervention in the early stages of cardiovascular disease.-
dc.description.sponsorshipThis work was supported by Grant SAF2013-48201-R from the Spanish Ministry of Economy and Competitiveness. C.G. was supported by a predoctoral fellowship from the University of Valladolid (Plan de Formación de Personal Investigador). CIBERDEM is an initiative of Instituto de Salud Carlos III.-
dc.publisherElsevier-
dc.relationMINECO/ICTI2013-2016/SAF2013-48201-R-
dc.relation.isversionofPostprint-
dc.rightsopenAccess-
dc.titleFoamy monocytes are enriched in cis-7-hexadecenoic fatty acid (16:1n-9), a possible biomarker for early detection of cardiovascular disease-
dc.typeartículo-
dc.relation.publisherversionhttps://doi.org/10.1016/j.chembiol.2016.04.012-
dc.date.updated2017-11-28T11:08:02Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.contributor.funderUniversidad de Valladolid-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007515es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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