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Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

AuthorsSala-Vila, Aleix; Navarro-Lérida, Inmaculada; Balsinde, Jesús ; Pol, Albert; Pozo, Miguel A. del
Issue Date2016
PublisherNature Publishing Group
CitationScientific Reports 6: 27351 (2016)
AbstractThe mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic processes, including steroid metabolism. Interestingly, we identified caveolin-1 (CAV1) as an integral component of hepatic MAMs, which determine the relative cholesterol content of these ER subdomains. Finally, a detailed comparative proteomics analysis between MAMs from wild type and CAV1-deficient mice suggests that functional CAV1 contributes to the recruitment and regulation of intracellular steroid and lipoprotein metabolism-related processes accrued at MAMs. The potential impact of these novel aspects of CAV1 biology on global cell homeostasis and disease is discussed.
DescriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.-- et al.
Publisher version (URL)https://doi.org/10.1038/srep27351
Identifiersdoi: 10.1038/srep27351
issn: 2045-2322
Appears in Collections:(IBGM) Artículos
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