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Title

Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

AuthorsVoelzmann, Andre; Okenve-Ramos, Pilar; Qu, Yue; Chojnowska-Monga, Monika; Caño-Espinel, Manuela del; Prokop, Andreas; Sanchez-Soriano, Natalia
Issue Date2016
PublishereLife Sciences Publications
CitationeLife 5: e14694 (2016)
AbstractThe mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Tau in regulating synapse numbers, thus unravelling an important cellular requirement of normal Tau. In this context, we find that Tau displays a strong functional overlap with microtubule-binding spectraplakins, establishing new links between two different neurodegenerative factors. Tau and the spectraplakin Short Stop act upstream of a three-step regulatory cascade ensuring adequate delivery of synaptic proteins. This cascade involves microtubule stability as the initial trigger, JNK signalling as the central mediator, and kinesin-3 mediated axonal transport as the key effector. This cascade acts during development (synapse formation) and ageing (synapse maintenance) alike. Therefore, our findings suggest novel explanations for intellectual disability in Tau deficient individuals, as well as early synapse loss in dementias including Alzheimer’s disease.
Publisher version (URL)https://doi.org/10.7554/eLife.14694.001
URIhttp://hdl.handle.net/10261/157781
DOI10.7554/eLife.14694.001
Identifiersdoi: 10.7554/eLife.14694.001
e-issn: 2050-084X
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