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Title

The carotid body does not mediate the acute ventilatory effects of leptin

AuthorsOlea, Elena ; Gallego-Martin, Teresa ; Yubero, Sara ; Rigual, Ricardo ; Obeso, Ana ; González, Constancio
KeywordsVentilation
Leptin
Catecholamine hypoxia
Carotid body
Issue Date2015
PublisherSpringer Nature
CitationArterial Chemoreceptors in Physiology and Pathophysiology: 379-385 (2015)
SeriesAdvances in Experimental Medicine and Biology 860
AbstractLeptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confi rm the stimulatory effect of leptin on ventilation, fi nding additionally that the CB does not mediate the instant to instant control of ventilation.
URIhttp://hdl.handle.net/10261/157692
Identifiersissn: 978-3-319-18439-5
Appears in Collections:(IBGM) Libros y partes de libros
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