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Experimental observations on the biological significance of hydrogen sulfide in carotid body chemoreception

AutorGallego-Martin, Teresa ; Agapito, Teresa ; Ramirez, Maria; Olea, Elena
Palabras claveCatecholamine
cAMP
Sulfide
Carotid body
TRPA1
Fecha de publicación2015
EditorSpringer Nature
CitaciónArterial Chemoreceptors in Physiology and Pathophysiology: 9-16 (2015)
SerieAdvances in Experimental Medicine and Biology 860
ResumenThe cascade of transduction of hypoxia and hypercapnia, the natural stimuli to chemoreceptor cells, is incompletely understood. A particular gap in that knowledge is the role played by second messengers, or in a most ample term, of modulators. A recently described modulator of chemoreceptor cell responses is the gaseous transmitter hydrogen sulfide, which has been proposed as a specific activator of the hypoxic responses in the carotid body, both at the level of the chemoreceptor cell response or at the level of the global output of the organ. Since sulfide behaves in this regard as cAMP, we explored the possibility that sulfide effects were mediated by the more classical messenger. Data indicate that exogenous and endogenous sulfide inhibits adenyl cyclase finding additionally that inhibition of adenylyl cyclase does not modify chemoreceptor cell responses elicited by sulfide. We have also observed that transient receptor potential cation channels A1 (TRPA1) are not regulated by sulfide in chemoreceptor cells.
URIhttp://hdl.handle.net/10261/157691
DOI10.1007/978-3-319-18440-1_2
Identificadoresdoi: 10.1007/978-3-319-18440-1_2
isbn: 978-3-319-18439-5
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