Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/157664
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function |
Autor: | Jourdain, Alexis A.; Simarro-Grande, María CSIC ORCID; Martinou, Jean-Claude | Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Cell Reports 10(7): 1110-1121 (2015) | Resumen: | The mitochondrial genome relies heavily on post-transcriptional events for its proper expression, and misregulation of this process can cause mitochondrial genetic diseases in humans. Here, we report that a novel translational variant of Fas-activated serine/threonine kinase (FASTK) co-localizes with mitochondrial RNA granules and is required for the biogenesis of ND6 mRNA, a mitochondrial-encoded subunit of the NADH dehydrogenase complex (complex I). We show that ablating FASTK expression in cultured cells and mice results specifically in loss of ND6 mRNA and reduced complex I activity in vivo. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis. These data provide insights into the mechanism and control of mitochondrial RNA processing within mitochondrial RNA granules. | Descripción: | Under a Creative Commons license.-- et al. | Versión del editor: | https://doi.org/10.1016/j.celrep.2015.01.063 | URI: | http://hdl.handle.net/10261/157664 | DOI: | 10.1016/j.celrep.2015.01.063 | Identificadores: | doi: 10.1016/j.celrep.2015.01.063 issn: 2211-1247 |
Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Mitochondria-Specific.pdf | 4,21 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
69
checked on 25-mar-2024
WEB OF SCIENCETM
Citations
68
checked on 26-feb-2024
Page view(s)
290
checked on 23-abr-2024
Download(s)
304
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons