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Adenosine receptor blockade by caffeine inhibits carotid sinus nerve chemosensory activity in chronic intermittent hypoxic animals

AuthorsSacramento, Joana F.; González, Constancio CSIC; Gonzalez-Martin, Carmen CSIC; Conde, Silvia V.
KeywordsCarotid sinus nerve activity
Chronic intermittent hypoxia
Hypoxic sensitization
Issue Date2015
PublisherSpringer Nature
CitationArterial Chemoreceptors in Physiology and Pathophysiology: 133-137 (2015)
SeriesAdvances in Experimental Medicine and Biology 860
AbstractAdenosine is a key excitatory neurotransmitter at the synapse between O2-sensing chemoreceptor cells-carotid sinus nerve (CSN) endings in the carotid body (CB). Herein, we have investigated the significance of adenosine, through the blockade of its receptors with caffeine, on the CB hypoxic sensitization induced by chronic intermittent hypoxia (CIH) in the rat. CIH animals were obtained by submitting rats during 15 days from 8:00 to 16:00 to 10 %O2 for 40 s and 20 % O2 for 80 s (i.e., 30 episodes/h). Caffeine (1 mM) was tested in spontaneous and 5 %O2 evoked-CSN chemosensory activity in normoxic and CIH animals. CIH decreased basal spontaneous activity but increased significantly CSN activity evoked by acute hypoxia. Caffeine did not modify basal spontaneous activity in normoxic rats, but decreased significantly by 47.83 % basal activity in CIH animals. In addition, acute application of caffeine decreased 49.31 % and 56.01 % the acute hypoxic response in normoxic and CIH animals, respectively. We demonstrate that adenosine contributes to fix CSN basal activity during CIH, being also involved in hypoxic CB chemotransduction. It is concluded that adenosine participates in CB sensitization during CIH.
Identifiersdoi: 10.1007/978-3-319-18440-1_15
isbn: 978-3-319-18439-5
Appears in Collections:(IBGM) Libros y partes de libros

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