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Protective effect of bioaccessible fractions of citrus fruit pulps against H2O2-induced oxidative stress in Caco-2 cells

AutorCilla, Antonio; Rodrigo, María Jesús ; Zacarías, Lorenzo ; Ancos, Begoña de ; Sánchez-Moreno, Concepción ; Barberá, Reyes; Alegría, Amparo
Palabras claveCitrus fruit pulps
Bioactive compounds
Antioxidants
In vitro digestion
Caco-2 cells
Oxidative stress
Fecha de publicación31-oct-2017
EditorElsevier
CitaciónFood Research International 103: 335-344 (2018)
ResumenFruit pulps from Navel (N) and Cara Cara (CC) oranges, and Clementine mandarin freshly harvested (M) and refrigerated stored (M12) were used to evaluate the cytoprotective effect of their bioaccessible fractions (BF) against H2O2-induced oxidative stress in Caco-2 cells. BF of samples preserved viability vs. H2O2 treated cells, reaching values similar to controls. Lipid peroxidation was reduced to levels of control cells, but M did not reach control values. ROS and mitochondrial membrane potential changes (Δψm) values were reduced compared with H2O2 treated cells, but without achieving control levels. A significant reduction in cell proportions in G1 phase and a significant increase in sub-G1 phase (apoptosis) of cell cycle was shown in H2O2 treated cells, and BF allowed a recovery close to control levels. Thus, BF of samples protect the cells from oxidative stress by preserving cell viability, mitochondrial membrane potential and correct cell cycle progression, and diminishing lipid peroxidation and ROS.
Versión del editorhttps://doi.org/10.1016/j.foodres.2017.10.066
URIhttp://hdl.handle.net/10261/157604
DOI10.1016/j.foodres.2017.10.066
ISSN0963-9969
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