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http://hdl.handle.net/10261/15751
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Araya, Eyleen | - |
dc.contributor.author | Rodriguez, Alex | - |
dc.contributor.author | Rubio, Jaime | - |
dc.contributor.author | Spada, Alessandro | - |
dc.contributor.author | Joglar Tamargo, Jesús | - |
dc.contributor.author | Llebaria, Amadeu | - |
dc.contributor.author | Lagunas, Carmen | - |
dc.contributor.author | Fernández, Andrés G. | - |
dc.contributor.author | Spisani, Susanna | - |
dc.contributor.author | Pérez, Juan J. | - |
dc.date.accessioned | 2009-08-06T07:46:53Z | - |
dc.date.available | 2009-08-06T07:46:53Z | - |
dc.date.issued | 2005-01-22 | - |
dc.identifier.citation | Bioorganic & Medicinal Chemistry Letters 15(5): 1493-1496 (2005) | en_US |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10261/15751 | - |
dc.description | 4 pages, 1 figure, 2 schemes, 1 table.-- PMID: 15713414 [PubMed].-- Printed version published Mar 1, 2005. | en_US |
dc.description.abstract | Peptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent computational study the natural product amygdalin was identified as a prospective peptidomimetic of the peptide and later proved to exhibit a similar chemotactic profile to the peptide. However, the cyanide moiety of amygdalin provides to the molecule a toxic profile. The present study reports the synthesis of a set of amygdalin analogs lacking the cyanide group with improved chemotactic profiles. | en_US |
dc.description.sponsorship | This research has been supported by the Spanish Ministry of Science and Technology through grant PTR1995-0404-OP-02-02. | en_US |
dc.format.extent | 22195 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Peptide T (ASTTTNYT) | en_US |
dc.subject | HIV | en_US |
dc.subject | AIDS | en_US |
dc.subject | Amygdalin | en_US |
dc.title | Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1016/j.bmcl.2004.12.071 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.bmcl.2004.12.071 | en_US |
dc.identifier.e-issn | 1464-3405 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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