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Título

Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T

AutorAraya, Eyleen; Rodriguez, Alex; Rubio, Jaime; Spada, Alessandro; Joglar Tamargo, Jesús; Llebaria, Amadeu; Lagunas, Carmen; Fernández, Andrés G.; Spisani, Susanna; Pérez, Juan J.
Palabras clavePeptide T (ASTTTNYT)
HIV
AIDS
Amygdalin
Fecha de publicación22-ene-2005
EditorElsevier
CitaciónBioorganic & Medicinal Chemistry Letters 15(5): 1493-1496 (2005)
ResumenPeptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent computational study the natural product amygdalin was identified as a prospective peptidomimetic of the peptide and later proved to exhibit a similar chemotactic profile to the peptide. However, the cyanide moiety of amygdalin provides to the molecule a toxic profile. The present study reports the synthesis of a set of amygdalin analogs lacking the cyanide group with improved chemotactic profiles.
Descripción4 pages, 1 figure, 2 schemes, 1 table.-- PMID: 15713414 [PubMed].-- Printed version published Mar 1, 2005.
Versión del editorhttp://dx.doi.org/10.1016/j.bmcl.2004.12.071
URIhttp://hdl.handle.net/10261/15751
DOI10.1016/j.bmcl.2004.12.071
ISSN0960-894X (Print)
1464-3405 (Online)
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