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Chitin synthesis and fungal cell wall morphogenesis

AuthorsRoncero, Cesar; Sánchez-Díaz, Alberto ; Valdivieso, María Henar
Issue Date2016
PublisherSpringer Nature
CitationBiochemistry and Molecular Biology: 167-190 (2016)
SeriesThe Mycota III
AbstractChitin is an extremely rigid natural polysaccharide and, hence, one of the most important structural biopolymers on earth. It constitutes an essential part of the fungal cell wall, where it is required for the maintenance of cell integrity. Interestingly, its importance does not only derive from its structural role as the major component of the primary septum (PS) but also from its function as a scaffold for the assembly of other components of fungal walls. The interconnections between chitin and other cell wall components determine cell morphogenesis, which is necessarily influenced by environmental changes. The variety observed in cell morphologies and environmental niches across the fungal kingdom would explain the high diversity of chitin synthases (CSs) present there, as well as their different regulatory mechanisms, making chitin synthesis a paradigm for studies addressing fungal morphogenesis. In addition, studies aimed at characterising the regulation of chitin synthesis are the basis for the development of new antifungal therapies.
Identifiersisbn: 978-3-319-27788-2
Appears in Collections:(IBFG) Libros y partes de libros
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