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An overview on medicinal chemistry of synthetic and natural derivatives of cannabidiol

AuthorsMorales, Paula ; Reggio, Patricia H.; Jagerovic, Nadine
KeywordsTherapeutic application
Molecular target
Cannabinoid receptor
Cannabidiol derivative
Issue Date2017
PublisherFrontiers Media
CitationFrontiers in Pharmacology 8 (2017)
AbstractCannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging.
Publisher version (URL)http://dx.doi.org/10.3389/fphar.2017.00422
Identifiersdoi: 10.3389/fphar.2017.00422
issn: 1663-9812
Appears in Collections:(IQM) Artículos
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