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dc.contributor.authorGiménez, María J.es_ES
dc.contributor.authorReal, Anaes_ES
dc.contributor.authorGarcía-Molina, María D.es_ES
dc.contributor.authorSousa Martín, Carolinaes_ES
dc.contributor.authorBarro Losada, Franciscoes_ES
dc.date.accessioned2017-11-07T13:45:02Z-
dc.date.available2017-11-07T13:45:02Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports 7: 42588 (2017)es_ES
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10261/157093-
dc.description.abstractSome studies have suggested that the immunogenicity of oats depends on the cultivar. RP-HPLC has been proposed as a useful technique to select varieties of oats with reduced immunogenicity. The aim of this study was to identify both the avenin protein patterns associated with low gluten content and the available variability for the development of new non-toxic oat cultivars. The peaks of alcohol-soluble avenins of a collection of landraces and cultivars of oats have been characterized based on the RP-HPLC elution times. The immunotoxicity of oat varieties for patients with celiac disease (CD) has been tested using a competitive ELISA based on G12 monoclonal antibody. The oat lines show, on average, seven avenin peaks giving profiles with certain similarities. Based on this similarity, most of the accessions have been grouped into avenin patterns. The variability of RP-HPLC profiles of the collection is great, but not sufficient to uniquely identify the different varieties of the set. Overall, the immunogenicity of the collection is less than 20 ppm. However, there is a different distribution of toxicity ranges between the different peak patterns. We conclude that the RP-HPLC technique is useful to establish groups of varieties differing in degree of toxicity for CD patients.es_ES
dc.description.sponsorshipThe Spanish Ministry of Economy and Competitiveness (Project IPT-2011-1321-010000), the European Regional Development Fund (FEDER) and Junta de Andalucía (Project P12-AGR-1762) supported this work.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleCharacterization of celiac disease related oat proteins: bases for the development of high quality oat varieties suitable for celiac patientses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/srep42588-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1038/srep42588es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.identifier.pmid28209962-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
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