English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/157011
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Cellular partners of the telomeric retrotransposons in Drosophila melanogaster

AuthorsLopez-Panades, Elisenda ; Casacuberta, Elena
Issue DateOct-2013
Citation23rd European Drosophila Research Congress (2013)
AbstractTelomere length is involved in processes like aging, tumorogenesis and genome stability and needs to be tightly regulated. Instead of telomerase, Drosophila uses three non-LTR retrotransposons, HeT-A, TART and TAHRE, (HTT), which transpose exclusively to telomeres to maintain telomere length. In Drosophila, telomere biology is based on a complex equilibrium between terminal transposition whenever telomere replication is needed, and tight control of telomere transposition in order to preserve genome stability. In order to understand the basis of this equilibrium, we have aimed to study the composition and life cycle of the telomere ribonucleoprotein (RNP). We have studied the localization in different tissues of the components of the telomere RNP (HTT proteins and mRNAs), as well as interacting partners of the telomere RNP that we have identified (Lost, Tral and NAP-1). We show that Nap1 is able to directly interact with HeT-A Gag, the telomere protein in charge of telomere targeting. Nap1 also interacts with different chromatin remodeling complexes like NURF and HP2. The direct interaction of these proteins with HeT-A Gag suggests a mechanism to target these chromatin remodeling complexes to the array of the telomeric retrotransposons, the HTT array. On the other hand, Lost and Tral are important players in the protection, processing, transport and localization of different mRNAs involved in germ line development. We are currently investigating the nature of the interaction between the telomere RNP and the Lost and Tral proteins.
DescriptionTrabajo presentado en el 23rd European Drosophila Research Congress (EDRC 2013), celebrado en Barcelona del 16 al 19 de octubre de 2013.
Appears in Collections:(IBE) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.