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Cellular partners of the telomeric retrotransposons in Drosophila melanogaster

AutorLopez-Panades, Elisenda ; Casacuberta, Elena
Fecha de publicaciónoct-2013
Citación23rd European Drosophila Research Congress (2013)
ResumenTelomere length is involved in processes like aging, tumorogenesis and genome stability and needs to be tightly regulated. Instead of telomerase, Drosophila uses three non-LTR retrotransposons, HeT-A, TART and TAHRE, (HTT), which transpose exclusively to telomeres to maintain telomere length. In Drosophila, telomere biology is based on a complex equilibrium between terminal transposition whenever telomere replication is needed, and tight control of telomere transposition in order to preserve genome stability. In order to understand the basis of this equilibrium, we have aimed to study the composition and life cycle of the telomere ribonucleoprotein (RNP). We have studied the localization in different tissues of the components of the telomere RNP (HTT proteins and mRNAs), as well as interacting partners of the telomere RNP that we have identified (Lost, Tral and NAP-1). We show that Nap1 is able to directly interact with HeT-A Gag, the telomere protein in charge of telomere targeting. Nap1 also interacts with different chromatin remodeling complexes like NURF and HP2. The direct interaction of these proteins with HeT-A Gag suggests a mechanism to target these chromatin remodeling complexes to the array of the telomeric retrotransposons, the HTT array. On the other hand, Lost and Tral are important players in the protection, processing, transport and localization of different mRNAs involved in germ line development. We are currently investigating the nature of the interaction between the telomere RNP and the Lost and Tral proteins.
DescripciónTrabajo presentado en el 23rd European Drosophila Research Congress (EDRC 2013), celebrado en Barcelona del 16 al 19 de octubre de 2013.
URIhttp://hdl.handle.net/10261/157011
Aparece en las colecciones: (IBE) Comunicaciones congresos
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