Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/156751
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Action of a diffusible target-derived chemoattractant on cortical axon branch induction and directed growth |
Autor: | Sato,M.; López-Mascaraque, Laura CSIC ORCID; Heffner, C.D.; O'Leary, D.D.M. | Fecha de publicación: | 1994 | Editor: | Cell Press | Citación: | Neuron 13: 791- 803 (1994) | Resumen: | Cortical axons innervate their brainstem target, the basilar pons, by the initiation and extension of collateral branches interstitially along their length. To address whether a diffusible pons-derived chemoattractant controls these events, we used cocultures in collagen matrices and time-lapse microscopy. Pontine explants enhanced by 5-fold the de novo initiation of transient branches along cortical axons; most branches were directed toward pons. Of the branches extended toward pons, 2%-3% were stabilized; those extended away were not. Pontine explants also enhanced the stable bifurcation of growth cones and prompted directional changes by growth cone turning and collateral extension. These effects were distance dependent and mimicked by pons-conditioned medium. This evidence indicates that the pons activity promotes branch initiation interstitially along cortical axons, a novel property for a chemoattractant, and provides a directional cue for their growth. These findings suggest that the pons chemoattractant serves as a diffusible target-recognition molecule. | URI: | http://hdl.handle.net/10261/156751 | DOI: | 10.1016/0896-6273(94)90246-1 | Identificadores: | doi: 10.1016/0896-6273(94)90246-1 issn: 0896-6273 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
78
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
77
checked on 27-feb-2024
Page view(s)
222
checked on 24-abr-2024
Download(s)
73
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.