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Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.

AutorMoratalla, Rosario ; Khairnar A; Simola N; Granado, Noelia ; García-Montes JR; Porceddu PF; Tizabi Y; Costa G; Morelli M.
Palabras claveRat
Non-human primate
Neuroinflammation neurotoxicity
Neurodegeneration
Mouse
Methamphetamine
3,4-Methylenedioxymethamphetamine
MDMA
Ecstasy
METH
Dopamine
Fecha de publicación2015
EditorPergamon Press
CitaciónProgress in Neurobiology 5: 58- 63 (2015)
ResumenAbstract Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and non-human primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. Copyright © 2015. Published by Elsevier Ltd.
URIhttp://hdl.handle.net/10261/156486
DOI10.1016/j.pneurobio.2015.09.011
Identificadoresdoi: 10.1016/j.pneurobio.2015.09.011
issn: 0301-0082
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